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best estrogen cream over the counter :: Article Creator Progesterone Cream: Benefits, Risks And Alternatives A reproductive hormone, progesterone is produced by the ovaries, adrenal glands and placenta (during pregnancy) says Kelly Culwell, M.D., a board-certified OB-GYN and Forbes Health Advisory member. Progesterone helps regulate the menstrual cycle and prepares the uterine lining, or endometrium, for pregnancy, she notes. "Specifically, progesterone supports early pregnancy by thickening and preparing the endometrium for a fertilized egg," says Michael Green, M.D., a board-certified OB-GYN in Lake Arrowhead, California, and co-founder of Winona, a telemedicine practice for women going through the menopause transition. Progesterone also supports the development of a pregnancy and encourages milk production during breastfeeding, adds Dr. Culwell. In women, high progesterone levels prevent ovulation during a pregnancy; in contrast, lo...